Officials in Iran lashed out on Tuesday at the latest round of sanctions imposed by the Trump administration, casting doubt on any hope of an imminent diplomatic end to the standoff over the Islamic Republic’s nuclear program. President Hassan Rouhani called the new U.S. sanctions “outrageous and idiotic,” and suggested the Trump administration was “afflicted by mental retardation” for imposing them.

The country’s foreign ministry spokesman said the latest move by the U.S. brought a “permanent closure” to any hope of diplomacy between the two nations.

President Trump imposed the new sanctions on Monday. For the first time they target Iran’s Supreme Leader Ayatollah Ali Khamenei directly, barring his access to the international financial system. The punitive measures — which add to a long list of financial sanctions already slapped on Tehran by Mr. Trump since he pulled the U.S. out of the nuclear deal with Iran last year — also target other officials.

Rouhani mocked Mr. Trump over the sanctions, saying: “You sanction the foreign minister simultaneously with a request for talks?”